Nature (RSS/Atom feed) on Nostr: Computational design of metalloproteases Nature, Published online: 14 October 2026; ...

Computational design of metalloproteases

Nature, Published online: 14 October 2026; [doi:10.1038/s41586-026-11167-2][1]

RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.

[1]: https://www.nature.com/articles/s41586-026-11167-2


https://www.nature.com/articles/s41586-026-11167-2